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特朗普打一针花掉230万,药品还包含脑白金?!一文为你解读懂王治疗方案(附视频&解说稿)

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自从10.2号特朗普在公众平台宣布他和他夫人患新冠肺炎开始隔离以来,关于特朗普与新冠的话题就一直是各大媒体讨论的对象 ,高居各大话题榜榜首,可以说,特朗普比国民明星还令人关注!

自从特朗普接受治疗以来,到底特朗普用了什么药,接受了什么治疗方法,一直广泛受到大众关注,毕竟美国可是世界上医疗最为发达的国家之一,特朗普所能接受的治疗,应该就是全球顶尖水平的治疗了,那么让我们关注一下,这个世界顶尖的治疗团队,是怎样治疗这个70多岁的老人的呢?





Trump’s coronavirus treatment, explained

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-The changing accounts from President Trump's doctors about his coronavirus treatment has created a credibility crisis for the White House.

-He has not received any supplemental oxygen?

-He's not on oxygen right now, that's right.

-In his lungs. Are there any [indistinct] - are there anything?

-Why were you so reluctant until today to disclose that the President had been administered oxygen.

-It's a good question.

-Thank you.

-I was trying to reflect the upbeat attitude of the team.

-And Sunday, Trump's medical team reported that his blood oxygen level dropped suddenly. It was the second time in recent days. A day later, however, the President's doctors said he was being discharged from the Walter Reed Medical Center and that he was continuing his treatment at the White House.

-Though he may not entirely be out of the woods yet, the team and I agree that all our evaluations and most importantly his clinical status - support the President's safe return home where he'll be surrounded by world -class medical care 24/7.

-The President has an aggressive mix of treatments, including a five-day regimen of an anti -viral medication as well as monoclonal antibodies, and experimental treatment still in clinical trials. He also receives steroids, vitamin B and Zinc, and an over -the -counter drug to reduce stomach acid. Howard Greller, a toxicologist who has seen many COVID patients, explains what each means. 

The first is Remdesivir, which is basically an antiviral agent. The best analogy to it would be something like Tamiflu, which is I think a drug that people are familiar with with influenza. It's still being studied. And here's where it gets tricky. It's primarily been used in patients who have been sick - hospitalized and sick. 

And part of the reason for that is because access to the drug has been limited. And part of it is we're still trying to figure out when is best to give the drug and who is best to give the drug to. You may have heard of that previously called convalescent plasma. So basically, people that survive having COVID, you then take out the antibodies from their blood and then use them to treat people who are actively combating the disease. This is something where it is a lab -created antibody -

- I believe it's two, which is why they're calling it a cocktail. They're looking at it in order to see whether or not it can both prevent and/or treat COVID. Dexamethasone is a drug that we've used therapeutically for decades. It's used in a host of inflammatory conditions ranging from asthma to different allergic conditions to arthri a whole host of things, and it's a potent steroid. This is by no means a cure -all. 

It's an additional tool to fight the virus but one that seems to have good data to support its use in sick people. Its effectiveness is questionable and certainly, it has some negative side effects to it, and it can have some significant side effects if too much is given. Yeah, I mean, vitamin D is an important vitamin, and it's an important thing, especially in people who are lighter skinned and who do not have regular sun exposure. And so, typically in winter time, Caucasian individuals are vitamin D deficient. It's PEPCID, to use the brand name. It's an antacid. 

There was an associating that was noticed that patients that were admitted with COVID that got Famotidine or were on Famotidine prior to hospitalization did a little bit better. But that association is not proof that Famotidine is a therapy. Adding more drugs, adding more therapies is not always better. I think that that's a really important point because the more you add, the more chance there is that you're gonna have an interaction or a problem amongst the things that you're adding. And when things have not been studied that say "A" goes with "B" really well, right, you're potentially introducing risk rather than benefit. That's why knowing a little bit more would be helpful in trying to parse this out.


10月5日特朗普总统医疗团队发布会



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Dr. Sean Conley: Good afternoon, everyone. Thank you for being here.

Dr. Sean Conley: Over the past 24 hours, the president has continued to improve. He’s met or exceeded all standard hospital discharge criteria. He’ll receive another dose of remdesivir here today, and then we plan to get him home. It’s been more than 72 hours since his last fever, oxygen levels, including ambulatory saturations and his work of breathing are all normal. Though he may not entirely be out of the woods yet, the team and I agree that all our evaluations, and most importantly his clinical status, support the president’s safe return home, where he’ll be surrounded by world-class medical care 24/7.

Dr. Sean Conley: I’d like to bring Dr. Dooley up to review some more specifics.

Dr. Sean Dooley: Good afternoon, just a brief update this morning. As Dr. Conley mentioned, the president continues to do very well. His vital signs this morning were notable for a temperature of 98.1, his blood pressure was 134 over 78, and a respiratory rate of 17 respirations per minute, and his heart rate was 68 beats per minute. His last oxyhemoglobin saturation was 97% on room air. He currently does not endorse any respiratory complaints, and aside from our evaluation with the multi-disciplinary team this morning, has maintained a full schedule, ambulating and working on the White House medical unit.

Dr. Sean Dooley: I’ll now turn it over to Dr. Garibaldi to again discuss therapeutics. Thanks.

Dr. Brian Garibaldi: Hi, good afternoon. Again, I just wanted to echo the sentiment of what an honor it is to be part of this wonderful team here at Walter Reed. Yesterday evening the president received his third dose of remdesivir and he tolerated that infusion without difficulty and his kidney and liver function continued to be normal. Our plan is to give the fourth dose of remdesivir this evening before he goes back to the White House. We’ve made arrangements to deliver the fifth and final dose of his treatment course at the White House tomorrow evening. He continues on dexamethasone and, again, the plan for today is to continue to be up and out of bed, eat and drink, and work as he is able.

Dr. Brian Garibaldi: I’d like to turn it over to Dr. Jason Blaylock, who’s an infectious disease specialist and the chief of medicine here at Walter Reed to give some updates on infection control. Thank you.

Dr. Jason Blaylock: Good afternoon, everyone. First of all, I just want to say what an honor it’s been to be part of this medical team behind me and to care for the president.

Dr. Jason Blaylock: Since the president’s arrival at Walter Reed, he’s received medical management that remains in line with national, clinical, societal guidelines for treatment of COVID-19 infection. In addition, both myself and Dr. Wes Campbell have worked very closely with various laboratories in the area, state-of-the-art facilities, to include USAMRAA and [RAR 00:03:10] on obtaining advanced diagnostic testing to really inform the White House medical team of both the status of the president, as well as his ability to transmit virus to others. Also, we have worked very closely with the Walter Reed team to ensure that we are looking very closely at infection control prevention strategies and the right posture so that the president can safely return to his residence.

Dr. Jason Blaylock: With that, I’m going to turn it over to Dr. Conley, who will answer any final questions?

Dr. Sean Conley: Thanks, Jason.

Dr. Sean Conley: I mentioned it Saturday, but I’d like to reiterate myself just how grateful the president and I are to the men and women of Walter Reed, our colleagues at Johns Hopkins, as well as the many federal, private institutions that we’ve received support from. So long as everything continues on the track that we’re experiencing right now, at this time, as the president already tweeted out, is to get him home later today. With that, I’ll take a couple questions.

Speaker 5: Dr. Conley, how can the president be discharged back to the White House when he was given steroids. You’ve said that he’s still on those steroids. Those are medicines, as you know, that are usually given to COVID patients who are on ventilators or with low oxygen, so did you over-treat him? If he’s still on that medication, how is it safe for him to return to the White House?

Dr. Sean Conley: We send patients home with medications all the time. In fact, yesterday afternoon, he probably met most of his discharge requirements safely from the hospital. He’s returning to a facility, the White House medical unit, that’s staffed 24/7, top-notch physicians, nurses, PAs, logisticians. The unit here, the team here behind me, is going to continue to support us in that nature.

Dr. Sean Conley: Yes?

Speaker 6: Dr. Conley. Dr. Conley, what are infection control measures are you taking and how was it safe for him to drive around in a cloth mask yesterday? How is it safe for him now to return to the White House where there’ve been so many cases? How’s any of this safe?

Dr. Sean Conley: The president has been surrounded by medical and security staff for days wearing full PPE. Yesterday, the US Secret Service agents were in that same level of PPE for a very short period of time. We’ve worked with our infectious disease experts to make some recommendations for how to keep everything safe down at the White House for the president and those around him. We’re looking at where he’s going to be able to carry out his duties, office space. I’ll just say that it’s in line with everything we’ve been doing upstairs for the last several days.

Speaker 7: Can you tell us please, on testing, can you tell us when he had his last negative test? Was it Thursday? Was it Wednesday? Do you remember when he had his last negative test?

Dr. Sean Conley: I don’t want to go backwards.

Speaker 7: It helps for contact tracing for people who were around him to know when he was positive.

Dr. Sean Conley: I understand. The contact tracing, as I understand it, is being done. I’m not involved in that.

Speaker 8: [crosstalk 00:06:19] that he leave or was this something he pushed for?

Dr. Sean Conley: No. We try to get patients home and out of the hospital as quickly as is safe and reasonable. Every day a patient stays in the hospital unnecessarily is a risk to themselves. Right now there’s nothing that’s being done upstairs here that we can’t safely conduct down home.

Speaker 9: You had said that seven to ten days was a window that you’d be concerned about. I don’t think we’re there yet. Do you have concerns about potential worsening or reversal? What are your plans for addressing that if it were to happen?

Dr. Sean Conley: You’re absolutely right. That’s why we all remain cautiously optimistic and on guard because we’re in a bit of unchartered territory when it comes to a patient that received the therapies he has so early in the course. We’re looking to this weekend. If we can get through to Monday with him remaining the same or improving, better yet, then we will all take that final deep sigh of relief. But as I said, 24/7 world-class medical care surrounding him down there. We’re not going to miss anything that we would have caught up here.

Speaker 10: Where is he physically going to be in the White House? What does that look like? How do you keep him safely quarantined?

Dr. Sean Conley: I wish I could go into that more, but I just can’t.

Speaker 6: Doctor, why did you begin dexamethasone treatment?

Dr. Sean Conley: Yesterday, we talked about that, the several little temporary drops in his oxygen, and we had discussed that as a team and elected to start it early in case that persisted or worsened. The potential risks and side effects, we all discussed. We looked at the data and decided that we’d rather, push ahead on it then hold and risk the opposite.

Speaker 6: What about CT scans and X-rays? What have you seen on his chest X-rays?

Speaker 11: [crosstalk 00:08:18] resume his campaigning?

Dr. Sean Conley: As far as travel goes, we’ll see.

Speaker 12: Dr. Conley, on his mental status, can you talk about whether he has any neurological symptoms? Does he have any side effects from his medications, any fogginess from the virus?

Dr. Sean Conley: No. I think you’ve seen the videos and now the tweets and you’ll see him shortly. He’s back. Yeah.

Speaker 6: What about his chest X-rays and CT scans?

Speaker 13: Have you seen any evidence of pneumonia or any inflammation in his lungs at all?

Dr. Sean Conley: We’ve done routine standard imaging, I’m just not at liberty to discuss.

Speaker 6: Doctor you were on board Air Force One.

Speaker 14: You’re actively not telling us what those lung scans showed, just to be clear.

Dr. Sean Conley: There are HIPAA rules and regulations that restrict me in sharing certain things for his safety and his own health and reasons.

Speaker 15: You said his oxygen dropped several times. Can you share how many times he was on oxygen? You said you would check with the nursing staff yesterday.

Dr. Sean Conley: Yeah. Yeah. Yes. Yes. Two episodes, like we talked about yesterday, and both times that he received a little bit of oxygen and recovered immediately.

Speaker 15: Was it required? Was that oxygen required?

Dr. Sean Conley: No, it wasn’t required. He wasn’t short of breath. He wasn’t looking ill. It was more of us trying to anticipate needs and see how he’d respond. In both cases, he came right off. He didn’t need it for very long at all.

Speaker 6: Doctor, you were on board Air Force One for multiple trips, are you at all concerned about your own exposure and exposure to the medical team?

Dr. Sean Conley: I am concerned, but as the CDC says, there are caveats for essential employees that as long as you continue to test negative, you remain symptom-free and you keep a mask on when you’re out and about, which we do inside the hospital, 24/7, then you can carry on your duties.

Dr. Sean Conley: Yeah?

Speaker 10: We all know the president’s an impatient man, has he been itching to get out of here?

Dr. Sean Conley: The president has been a phenomenal patient during his stay here. He’s been working hand in glove with us and the team. Today it got to the point, he’s holding court with those of us around him, the whole team, going over all the specifics, the testing, what the future is, and we have been back and forth on what’s safe, what’s reasonable. He has never once pushed us to do anything that was beyond a safe and reasonable practice that we all first wanted.

Speaker 16: Was there anybody on this medical team, who recommended against the president leaving here and going back to the White House today?

Speaker 16: Or any White House staffers?

Dr. Sean Conley: No.

Speaker 6: The president said, “Don’t be afraid of COVID.” Do you agree with that? Should we not be afraid?

Dr. Sean Conley: I’m not going to get into what the president says.

Speaker 17: You said his heart, liver, and kidney function was normal or improving. Improving, does that mean that there were effects and is it all normal? What’s up with that?

Dr. Sean Conley: Yeah. It’s all normal right now. I would say he appeared to be a little dehydrated Friday. He was able to just drink and recover from that. Yeah, everything looks great.

Speaker 18: Doctor, what would you like to see before he starts, resumes campaigning out in the country? What sort of things do you want to see?

Dr. Sean Conley: Yeah. The big first thing that we need to do is that there is no evidence of live virus still present that he could possibly transmit to others, and that’s what the infectious disease experts and some of our partners, military, civilian entities doing some of these advanced diagnostics just to see, as soon as we can identify that routinely. We talk about a 10-day window, CDC guidelines, but we’re checking him more routinely than just waiting 10 days. There’s a possibility it’s earlier than that. There’s a chance that it’s a little bit later, but we will know as soon as possible. Then we will look at him clinically. How are you feeling? How are you doing?

Speaker 19: Why have you decided not to use, administer hydroxychloroquine to the president during his time here?

Dr. Sean Conley: I’m not going to go into all of our debates about specific medicines and therapies. There are dozens of therapies that we were made aware of that we considered, that we discussed and debated and looked at the existing literature on. This is the regimen we chose.

Speaker 19: [crosstalk 00:12:44] hydroxychloroquine.

Dr. Sean Conley: Yeah?

Speaker 20: On the symptoms of COVID, is he’s having some of the muscle aches? Has he lost his sense of taste and smell?

Dr. Sean Conley: No. We were just talking about that, what symptoms he has left. Even the slight cough that he used to have, he doesn’t really complain of at all. He hasn’t ever complained of a muscle aches. Yeah, he’s up and back to him old self, predominantly.

Speaker 10: You talked about next Monday, just to be clear, how long will he still be actively shedding the virus?

Dr. Sean Conley: This morning, I believe there was even an accounting by Dr. Fauci referencing a five day, the first five days of illness that people are most likely to shed live virus. There’s a reason there’s the 10 days. It’s because most people, by that time, after seven days, most folks don’t have culturable live virus. They put it to 10, just to give some extra space. It’s never 100% between everybody, so we’ll see. I’m not going to put a specific number, but we look at that window is all I will say.

Speaker 21: Doctor, will the president be confined to his residence or will he be allowed to return to the Oval Office?

Dr. Sean Conley: We’re going to do whatever it takes for the president to safely conduct business, whatever it is he needs to do within the residence and White House.

Speaker 22: Is he on blood thinners? Also, has he been using, have you been giving him Tylenol, Advil, anything to bring his fever down?

Dr. Sean Conley: Oh, that came up. I would like to say, he has not been on any fever-reducing medications for over 72 hours.

Speaker 22: But what about the blood thinners?

Dr. Sean Conley: Yeah. He’s on a routine regimen of COVID therapy. I’m not going to go into specifics as to what he is and is not on, but …

Speaker 23: You said, I’m going to read this here, that the president had a mild cough, some nasal congestion and fatigue on Thursday. Now back to my colleague, John Jacobs question, the reason knowing when the president’s last negative test is important for that reason, your words, what you said, and also for the contract tracing, but would you’ve recommended that given those symptoms that he go, that the president go to that Bedminster fundraiser?

Dr. Sean Conley: It’s not up to me, necessarily, the president’s schedule, but I would say that it wasn’t until after he returned that we really sat down, then knowing the news of the day that we really dove into, how are you feeling? What’s going on?

Speaker 23: But how was that safe given that those were the symptoms he was experiencing on Thursday?

Dr. Sean Conley: I’m not going to get into operations.

Speaker 6: Doctor, one last time, when was his last negative test and what was his viral load?

Dr. Sean Conley: I know everyone wants that.

Speaker 6: We’ve been exposed. [crosstalk 00:15:24]

Dr. Sean Conley: Yeah. I I don’t have his viral load. Those are some of the diagnostics that we’re sending out that will really tell us when it’s safe for him to get back out and around people.

Speaker 6: You’ve never had his viral load?

Speaker 24: Why is it [crosstalk 00:15:37] say when the last negative test was?

Speaker 25: Did he have any abnormal tests? Were any of his lab tests abnormal?

Dr. Sean Conley: Again, HIPAA kind of precludes me from going into too much depth on things that I’m not at liberty or he doesn’t wish to be discussed. At some future point, maybe. But today, I’m sorry. I think that’s it. Yeah.

Speaker 26: Thank you, guys, so much.

Dr. Sean Conley: Thank you.

Speaker 26: Thank you.




1


2天服用7种药物,
史无前例的超大剂量与混合应用,
治疗方案中惊现脑白金(褪黑素)?
 
白宫医生肖恩 康利(Sean Conley)现在是总统特朗普的健康发言人。虽然他的消息与白宫以及总统本人的不太一致。

10月4日,他在特朗普住院的Walter Reed陆军医院召开的发布会上称,总统经过治疗,目前已退烧

这位骨科医生出身的白宫医生,带领一个由九人组成的医疗团队:两名肺部重症监护医生,一名肺部危重病护理医生,两名传染病医生,一名麻醉师,一名临床药剂师,一名执行医学计划主任,三名护士为总统进行新冠治疗。

做为总统的医疗与健康的总负责人,他有权力来做出任何治疗新冠的决定,虽然他本人根本不是传染病方面的专家。他在当天的发布会上,强调特朗普目前没有吸氧,呼吸没有问题,心脏及肾脏情况正常,亦可如常走动

但医生表示他目前情况是“not yet out of the woods”,即尚未完全脱离危险。目前认为COVID-19病程常超过两周,需要在首发症状出现7-10天后才能判断疾病是否好转

但记者们却对他之前开出的总统治疗方案以与处方提出了许多质疑。在3天的时间内,白宫御医肖恩·康利给特朗普使用了“多克隆”抗体鸡尾酒疗法、锌,维生素D,法莫替丁,褪黑素(脑白金),阿司匹林等6种药物,10月2日下午,为了谨慎起见,又将总统送入了Walter Reed陆军医院,当晚开始使用瑞德西韦(“人民的希望”)。第二天与第三天也分别服用了瑞德西韦。

这份治疗方案中的一个数字引起了媒体与医护人员的关注:治疗方案备忘录显示,特朗普将接受一剂8克的抗体混合物治疗。这种实验药品是由美国再生元制药公司研发的,而根据该公司的标准,8克属于大剂量(high dose)

如此大的剂量对于一个74岁有着超重身体的老人来说,剂量是否有点太大?

而这份治疗方案中出现的一个熟悉的配方:褪黑素(脑白金)也引发了人们的关注,这个也可以治疗新冠感染

3天内用7种不同的药物进行史无前例的大剂量治疗,其中有两种还在试验中并未获得任何批准的药物,而另外四种,根本与新冠感染病症治疗无关

白宫医疗团队给特朗普制定如此激进的治疗方案,来自于何种医学考虑?是谁做的这个决定?是否符合治疗规范,会否给特朗普带来不可逆转的副作用?

10月5日特朗普总统医疗团队发布会


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-This morning, the president is doing very well. Just 72 hours into the  diagnosis now, the first week of COVID and in particular days 7 to 10 are the most critical in determining the likely course of this illness. Thursday he had a mild cough and some nasal congestion and fatigue, all of which are now resolving and improving.

-We have monitored his cardiac function, his kidney function, his liver  function. All of those are normal. And the president this morning is not on oxygen.

-About 48 hours ago, the president received a special antibody therapy directed against the coronavirus, and we're working very closely with the company to monitor him. Yesterday evening, he received his first dose of IV remdesivir, and our plan is to continue a 5-day treatment course for remdesivir.

-The president's been fever-free for over 24 hours. We remain cautiously optimistic, but he's doing great.

-Do you have an estimated date when he might be discharged?

-Well, I don't want to put a hard date on that. Given that we provided some of these advanced therapies so early in the course, a little bit earlier than most of the patients we know and follow, it's hard to tell where he is on that course. We are maximizing all aspects of his care, attacking this virus in a multipronged approach. It's the president. I didn't want to hold anything back. If there was any possibility that it would add value to his care and expedite his return, I wanted to take it.

-Has he ever been on supplemental oxygen?

-Right now he is not on oxygen.

-I understand. I know you keep saying "right now." But should we read into the fact that he had been previously?

-Yesterday and today, he was not on oxygen.

-When was the president's diagnosis made? You said 72 hours. That would put it at Wednesday.

-So, Thursday afternoon, following the news of a close contact, is when we repeated testing and given kind of clinical indications to add a little bit more concern, and that's when late that night we got the PCR confirmation.

-In addition to his weight, does he have any other risk factors that make him more at risk for sort of a severe case?

-Well, not particularly. He's 74. He's male. And he is slightly overweight.

-So, why was the decision made to transfer him here?

-Because he's the president of the United States.

-Why wasn't the first lady admitted, as well?

-The first lady's doing great. Thanks for asking. She has no indication for hospitalization, advanced therapy. She's convalescing at home. Thank you.




2


 
老特为何会使用尚未批准的新冠疗法:
抗体鸡尾酒疗法单克隆抗体
是新冠神药?8克超强大剂量,
是否意味着他的病情严重?
 
治疗方案备忘录中,这款引发医学界质疑与争议的尚未批准的试验性药物,抗体鸡尾酒疗法,因为其大剂量的应用,以及其9月30刚公布二期试验结果,就开始用于治疗,而引发人们的质疑,甚至美国著名期刊《科学》杂志还刊发专文,讨论剂量问题的使用与副作用问题。

特朗普使用的抗体鸡尾酒疗法,是再生元公司(Regeneron)的REGN-COV2。这款鸡尾酒,包含了两种单克隆抗体 (REGN10933 和 REGN10987),分别针对新冠病毒刺突蛋白受体结合区域的 2 个不同位点。需要指出的是,白宫御医的文件中说这鸡尾酒是“多克隆抗体”,这是一个错误的说法。

单克隆抗体、多克隆抗体制造的方法各不相同,两个单克隆抗体合在一起当“鸡尾酒”使用,还是单克隆抗体。对此,再生元公司发言人Hala Mirza对CBS新闻表示:“这是两种单克隆抗体,将之称为多克隆抗体是不正确的”。


当然,REGN-COV2 是一种目前尚未被 FDA 批准的疗法

在9 月 30 日,再生元刚刚公布了 REGN-COV2 在无缝连接的 1/2/3 期临床试验中获得的初步结果:在对 275 名非住院的新冠患者进行临床试验治疗后发现,对于血清中抗病毒抗体浓度较低的患者,鸡尾酒疗法可以降低病毒数量,尤其对于治疗前病毒量很高的患者,鸡尾酒的效果更为显著。在临床试验中,鸡尾酒抗体只注射一次,测量患者的病毒量,是在治疗7天后。
 
血清中抗病毒抗体浓度较低,说明患者尚未产生有效的免疫反应。从另外一个角度来说,如果体内已经产生了比较高浓度的抗病毒抗体,鸡尾酒疗法也就不需要了。所以,从使用的时间窗口上,应该是刚刚感染的患者,以及感染后迟迟不能产生大量抗病毒抗体的患者。
 
在白宫御医的文件中,提到鸡尾酒抗体的剂量是8克。有人对此很惊讶,因为一般的抗体治疗都是毫克级,为什么抗新冠的鸡尾酒需要这么多?
 
在再生元的鸡尾酒临床试验中,其实测试了两种剂量:2.4克和8克。但是,2.4克剂量治疗后,患者的病毒量虽然也有降低,但是降低并没有显著性。所以,这款鸡尾酒,要不就不用,要用就得用8克。其他的公司也在进行新冠抗体的临床试验,使用的也是克级的抗体剂量。

 

3


8克单抗大约是33万美元?
特朗普未批准使用走的是“同情使用”渠道
 
在特朗普目前使用的这七种药物中,真正用于新冠治疗的是瑞德西韦与单克隆抗体。特朗普所用的这两个药物,价格都很贵

瑞德西韦在美国一个疗程是 3120 美元,人民币约21800元。而 REGN-COV2 目前还没有公布价格,但是这个药物本质上是一种单克隆抗体。

如果这款鸡尾酒抗体疗法获得了批准,会是什么价格呢?网上有一个四处流传的视频,说特朗普这一针,“打掉了一套北京三环的房子”,因为一般的抗体治疗都是毫克级的。这也是耸人听闻的说法,但也正因为如此,特别吸引眼球。

单克隆抗体的生产复杂且昂贵,目前最广为人知的单克隆抗体,可能是肿瘤患者使用的 PD-1 抑制剂,PD-1单抗K药一年的治疗费用大约15万美元,剂量是每3个星期注射200毫克,如果按照K药价格来折算,8克单抗大约是33万美元,或者230万人民币。北京三环的房子应该没有这么便宜。当然,230万人民币也是一个巨大的经济负担,这是未来必须面对的问题。如果不考虑药物的科研成本,仅仅考虑生产成本,8克单抗可以几千美元搞定。

至于美国总统是否行使了特权,优先使用了一款尚未批准的药物?确实并不是每个人都有机会这样做,但是这样的操作并不少见。这款鸡尾酒属于“同情使用”,在今年1月,美国的第一例新冠患者,是一个华人,当时使用瑞德西韦治疗,也是“同情使用”。

| 10月3日,特朗普在沃尔特军事医学中心的总统套房发布的工作照,宣布自己仍然可以处理国政。


4


特朗普为何会放弃使用羟氯喹,
而选择硫酸锌?
 
锌怎么跟治疗新冠扯上了关系?

美国有一个医生,叫泽伦科(Vladimir Zelenko)。在今年3月,泽伦科就声称收治了699位新冠患者,使用“硫酸羟氯喹片+阿奇霉素片+硫酸锌”三联疗法,“0名患者死亡,0名患者插管,有效率100%”。泽伦科将此疗法推荐给了总统

此前,美国FDA曾经批准硫酸羟氯喹和磷酸氯喹,作为新冠治疗的紧急使用,但是此后严格的临床试验并未能证实羟氯喹的疗效,因此目前已经撤销上述药物的紧急使用。

在今年5月,白宫御医康利就已经给总统开了羟氯喹的处方药,作为预防性药物服用。即便临床试验未能证明其疗效,特朗普还是特别推崇羟氯喹,并将其推荐给了巴西总统,后者在确诊新冠后也曾服用。
 
在10月3日的发布会上,康利表示目前特朗普并未服用羟氯喹。特朗普在确诊后问询过是否能服用羟氯喹,但是经过讨论,特朗普放弃。这其中原因,应该是考虑到羟氯喹在新冠患者中使用时的心脏病风险,如果与阿奇霉素联用,风险更高
 
但是在泽伦科的神奇三联治疗中的锌,则是一个保健品,安全性没有问题,所以出现在总统的治疗套餐中,就不奇怪了。


5



缺乏维生素D的人感染新冠的风险较高,
但不能治疗新冠,
总统处方中的维D,是保健品?


9月3日,《JAMA 网络开放》杂志发表了一篇论文,表明维生素D缺乏的人感染新冠的风险较高。这份研究调查了489名此前检查过体内维生素D含量的人士,其中79人感染了新冠,维生素D缺乏者感染新冠的风险是不缺乏者的1.77倍(1)。
 
需要指出的是,这只是一个流行病学的调查,并不能完全表明补充维生素D就能预防新冠,更不能作为使用维生素D治疗新冠的证据。加拿大卑诗大学医学系教授及温哥华综合医院肠胃科医生吉田指出,没有证据表明锌可以治疗新型冠状病毒。事实上,锌对新冠病毒没有任何帮助。
 
但是作为一种保健品,维生素D安全性没有大问题,所以出现在总统治疗套餐里,也不奇怪。



6


褪黑素(脑白金):对,
你没有看错,是脑白金。
德州一医生称用脑白金治疗了400个新冠患者,
部分有效?

褪黑素大家不知道是什么,但是一说脑白金,很多人都会想起“今年过年不收礼,收礼只收脑白金”的广告语。
 
褪黑素也是一个普通的保健品,但是经过史玉柱的包装,在中国成了一个营销的传奇。

特朗普服用的脑白金,肯定不是史玉柱的礼物,这种保健品在美国满大街都是。但是,为什么御医的文件中会在治疗方案中提到脑白金(褪黑素)呢?
 
得克萨斯州的一个医生,Dr. Richard Neel, 声称已经使用脑白金治疗了400个新冠患者,虽然目前还是有小部分人仍在与疾病斗争,但是大部分都有效。
 
从这个表述中,其实大家能够意识到这并不是一个临床试验,并不是确认“有效”是否是“脑白金”的效果。但是,这毕竟是一个正能量(positive)的消息,目前疫情严重的美国,就需要这样正能量的消息。

另有消息称,这个褪黑素也是德州医生推荐给特大统领的
 
Stay positive. Be patient.
 
另有媒体推测特朗普用这种药,可能是预防呼吸困难导致的睡眠问题。脑白金也是保健品,安全性没有大问题,所以出现在总统治疗套餐里,也不奇怪。



7


法莫替丁使近900名新冠患者降低了死亡?
这款试验性未经证实有效的药物,
为何会出现在治疗方案中
 
法莫替丁是一款治疗胃溃疡的非处方药物,美国目前有医院正在进行临床试验,研究是否能使用法莫替丁治疗新冠。
 
发起这个临床试验的,是纽约州范斯坦医学研究所(Feinstein Institutes for Medical Research)所长特雷西(Kevin Tracey)。特雷西的灵感,来自中国新冠患者中的发现:部分服用法莫替丁的新冠患者,情况比未服用该药的患者更好
 
9月2日,哈特福德医疗保健中心的一份研究也表明,在该医疗中心的900名住院患者中,83人使用过法莫替丁。调查表明,服用过法莫替丁的患者,在医院死亡的可能性降低了45%,需要使用呼吸机的可能性也降低了48%。同时,使用法莫替丁的患者中,一些血液检测指标也降低了,而这些指标与新冠预后不佳有关。


需要指出的是,这也并不是一个正规的临床试验,只是一个流行病学调查。目前还没有正式的临床试验结果报道
 
但是,作为一个非处方药物,法莫替丁的安全性不是大问题,所以出现在总统治疗套餐里,也不奇怪。


8



阿司匹林:防凝血还是防新冠? 
 
新冠患者容易出现血栓的问题,阿司匹林作为一个防止凝血的药物,自然有人猜测可以用来治疗新冠。
 
但是,目前并没有阿司匹林可以治疗新冠的临床证据,阿司匹林也容易引起出血,也是必须谨慎使用的



9


 与单抗隆抗体、法莫替丁联合,

连续五天使用瑞德西韦,会出现奇迹吗?
 
在入住Walter Reed陆军医院的当晚,特朗普开始使用瑞德西韦治疗。根据报道,治疗将持续5天。
 
在以上的所有药物中,瑞德西韦是美国目前获得紧急授权,用于新冠治疗的药物。瑞德西韦的治疗效果并没有一开始预期的那么优秀,尤其是在中国的临床试验中,几乎没有获得必要性进展。这款药物的使用,据称是将其与单克隆抗体、法莫替丁进行联合例用之后,以期获得更好的效果。
 
总结一下,有媒体称这份治疗方案,从某种程度上讲代表了目前现代医学应对新冠肺炎所能拿出的一个折衷方案,但肯定不是一个最佳方案。并质疑这样的方案能否让特朗普顺利治愈并康复

在确诊后的一天内,他就已经使用了多种药物(保健品)进行治疗。从这份治疗方案中,也看到了慌乱与过度治疗。这些药物要么是还在试验中,要么还没有定论,要么有严重的副作用。这里面的一些药物、保健品,单独使用并没有问题,但是一下子使用那么多种药联用,是否会导致不良反应以及严重的后遗症?
 
有消息说,特朗普已经有24小时没有发烧了,这是一个好消息,但是未来的几天仍旧是关键。


如果特朗普治好了,到底是鸡尾酒的效果,还是瑞德西韦的效果?可能会有很多人认为,这是脑白金(褪黑素)的效果。

中文部分转载自CC周刊公众号,微信号:cancer-weekly。




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